Visioli et al. [1] showed that Oleuropein increases nitric oxide (NO) production in macrophages challenged with lipopolysaccharide through induction of the inducible form of the enzyme nitric oxide synthase, thus increasing the functional activity of these immunocompetent cells. It is well known that Oleuropein elicits anti-inflammatory effects by inhibiting lypoxygenase activity and the production of leukotriene B4 [2].

• Biological Activities of Phenolic Compounds Present in Virgin Olive Oil
• Healthful Properties of Olive Oil Minor Components
• Effects of virgin olive oil phenolics on scavenging of reactive nitrogen species and upon nitrergic neurotransmission.
• Protective effect of oleuropein, an olive oil biophenol, on low density lipoprotein oxidizability in rabbits.
• Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil.
• Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans.
• Oleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extract
• Evaluation of the Effect of Oleuropein on Alveolar Bone Loss, Inflammation, and Apoptosis in Experimental Periodontitis
• Oleuropein Inhibits the IL-1β-induced Expression of Inflammatory Mediators by Suppressing the Activation of NF-κB and MAPKs in Human Osteoarthritis Chondrocytes
• Oleuropein Suppresses Oxidative, Inflammatory, and Apoptotic Responses Following Glycerol-Induced Acute Kidney Injury in Rats
• Anti-inflammatory Effect of Oleuropein on Microglia Through Regulation of Drp1-dependent Mitochondrial Fission
• [1] Visioli F, Bellosta S, Galli C.
  Oleuropein, the bitter principles of olives, enhances nitric oxide production by mouse macrophages.
  Life Sci. 1998; 62: 541–546. doi:10.1016/S0024-3205(97)01150-8
• [2] Manna C, Migliardi V, Golino P, Scognmiglio A, Galetti P, Chiariello M, Zappia V.
  Oleuropein prevents oxidative myocardial injury by ischemia and reperfusion.
  J Nutr Biochem. 2004; 15: 461–468. doi:10.1016/j.jnutbio.2003.12.010