Visioli and Galli reported that Oleuropein shows anti-atherogenic activity [1]. In 2003, Carluccio MA et al. [2] reported that Oleuropein reduces monocytoid cell adhesion to stimulated endothelium as well as vascular cell adhesion molecule-1 (VCAM-1) mRNA and protein. Reflow in ischemic hearts was accompanied by a prompt release of oxidized glutathione; in ischemic hearts pretreated with Oleuropein, this release was significantly reduced and was accompanied by prevention of membrane lipid peroxidation, which is considered a key factor in the pathogenesis of atherosclerosis [1].

• [1] De la Puerta R, Guttierrez VR, Hoult JRS.
  Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil.
  Biochem Pharmacol. 1999; 57: 445–449. doi:10.1016/S0006-2952(98)00320-7
• [2] Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C, Visioli F, Distante A, De Caterina R.
  Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals.
  Arterioscler Thromb Vasc Biol. 2003;23(4):622–629. doi:10.1161/01.ATV.0000062884.69432.A0